Detaillierte Beitrags-Information
| Beitragstitel | Deciphering Metabolic Migraine |
|---|---|
| Beitragscode | P15 |
| Autor:innen | |
| Präsentationsform | Poster |
| Themengebiete |
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| Abstract-Text |
Background: Migraine is a primary headache disorder, which affects approximately 12 percent of the population. Previous studies demonstrated that a subgroup of migraine patients experience migraine attacks triggered by metabolic stressors indicating low energy levels in the brain. Moreover, this metabolic subtype of migraine is presumed to be related to mitochondrial abnormalities. The aim of this study is to identify this subgroup of migraine patients in order to personalize patient treatment. We expect these patients to respond particularly well to targeted supplements or lifestyle interventions. Material and Methods: We designed a questionnaire which focuses on questions unmasking metabolic migraine triggers. For this project, 100 patients with diagnosed migraine (with or without aura) and previous visits to our headache clinic will be recruited to respond to our questionnaire. So far, 14 patients completed the questionnaire. In a preliminary analysis, we here show how many patients had indicators for metabolic migraine (sensitivity to one or more metabolic triggers) and analyze their baseline characteristics. In addition, we correlate the presence of metabolic migraine with baseline characteristics as well as with response to treatment. Results: 6 of the 14 patients cited missed meals or fasting periods as triggers for their migraine attacks, supporting the fact that low energy levels in the brain may cause migraine. In addition, 4 out of these 6 patients stated a relief of their headache problems by taking supplements such as magnesium, coenzyme Q10 and/or riboflavin. In contrast, only 2 of the other 8 patients showed relief with these supplements. Since these substances are known to support the mitochondrial function, this finding suggests mitochondrial impairment without this treatment, thus indication for metabolic migraine. Conclusion: Our first preliminary results provide evidence that metabolic triggers are present in a subgroup of migraine patients. Furthermore, there could be a correlation between sensitivity to metabolic triggers and response to treatment with supplements. However, the current sample size is too small to detect significant differences between patient groups. Further data will be collected and evaluated until the convention in April. |